libncbi-vdb-dev - 2.10.9+dfsg-2 main

Much of the data submitted these days, for example in BAM, Illumina
export.txt, and Complete Genomics formats, contain alignment
information. With aligned data, NCBI uses Compression by Reference,
which only stores the differences in base pairs between sequence data
and the segment it aligns to. The process to restore original data, for
example as FastQ, requires fast access to the reference sequences that
the original data was aligned to. NCBI recommends that SRA users
dedicate local disk space to store references downloaded from the NCBI
SRA site. As of Fall 2014, the complete collection of these reference
sequences is 66 GB. While it isn't usually necessary to download the
entirety of the reference sequences, this should give you an idea of the
scale of the storage requirement. By default, the Toolkit will download
missing reference sequences on demand and cache them in the user's home
directory. The location of this cache is configurable, as is whether the
download is automatic or manual.
.
This is the development package.