provean - 1.1.5+ds-2 main

PROVEAN (Protein Variation Effect Analyzer) is a software tool which predicts
whether an amino acid substitution or indel has an impact on the biological
function of a protein.
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PROVEAN is useful for filtering sequence variants to identify nonsynonymous or
indel variants that are predicted to be functionally important.
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The performance of PROVEAN is comparable to popular tools such as SIFT or
PolyPhen-2.
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A fast computation approach to obtain pairwise sequence alignment scores
enabled the generation of precomputed PROVEAN predictions for 20 single AA
substitutions and a single AA deletion at every amino acid position of all
protein sequences in human and mouse.